Proteomic analysis of mitochondria in Raji cells following exposure to radiation: implications for radiotherapy response

Protein Pept Lett. 2009;16(11):1350-9. doi: 10.2174/092986609789353646.

Abstract

Radioresistance represents a major obstacle to a successful outcome for the treatment of non-Hodgkin's lymphoma (NHL). Here we performed a global differential proteome analysis of the mitochondria in Raji cells exposed to radiation. The results showed that 23 differentially expressed proteins were identified. Furthermore, GAPDH, RECQL4, MKI67, and ATAD3B could serve as potential biomarkers of radioresistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Biomarkers, Tumor / radiation effects*
  • Cell Line, Tumor
  • Cell Proliferation / radiation effects
  • Computational Biology
  • Flow Cytometry
  • Gene Expression Regulation, Neoplastic / radiation effects
  • Humans
  • Lymphoma, Non-Hodgkin / genetics
  • Lymphoma, Non-Hodgkin / metabolism
  • Lymphoma, Non-Hodgkin / pathology
  • Lymphoma, Non-Hodgkin / radiotherapy*
  • Mitochondria / metabolism*
  • Mitochondria / radiation effects*
  • Proteome / radiation effects*
  • Proteomics / methods
  • Radiotherapy
  • Reproducibility of Results

Substances

  • Biomarkers, Tumor
  • Proteome