Reference values for N-terminal pro-B-type natriuretic peptide in fetal circulation between 20 and 34 weeks of gestation

Waltraut M Merz; Kirsten Kübler; Eike Albers; Birgit Stoffel-Wagner; Ulrich Gembruch

doi:10.1016/j.clinbiochem.2009.11.012

Reference values for N-terminal pro-B-type natriuretic peptide in fetal circulation between 20 and 34 weeks of gestation

Clin Biochem. 2010 Mar;43(4-5):519-21. doi: 10.1016/j.clinbiochem.2009.11.012. Epub 2009 Dec 5.

Authors

Waltraut M Merz¹, Kirsten Kübler, Eike Albers, Birgit Stoffel-Wagner, Ulrich Gembruch

Affiliation

¹ Department of Obstetrics and Prenatal Medicine, University of Bonn Medical School, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. Waltraut.Merz@ukb.uni-bonn.de

PMID: 19968983
DOI: 10.1016/j.clinbiochem.2009.11.012

Abstract

Objective: We aimed to investigate the range of fetal NT-proBNP values in normal pregnancy between 20 and 34 weeks of gestation.

Method: NT-proBNP was measured in 56 fetal blood samples.

Results: Mean (+ or - 2 SD) NT-proBNP concentration was 1998 (242-3754) ng/L; a significant decline occurred with advancing gestational age (p=0.012).

Conclusions: Gestational age has to be taken in to consideration in the assessment of NT-proBNP. Our data may be used as reference values in fetal and neonatal medicine.

MeSH terms

Female
Fetal Blood / metabolism*
Gestational Age*
Humans
Natriuretic Peptide, Brain / blood*
Peptide Fragments / blood*
Pregnancy
Reference Values

Substances

Peptide Fragments
pro-brain natriuretic peptide (1-76)
Natriuretic Peptide, Brain