A new 5-acyl-2-methylpyrrole from the endophytic fungus S20 of Cephalotaxus hainanensis

Nat Prod Commun. 2009 Nov;4(11):1489-90.

Abstract

A new 5-acyl-2-methylpyrrole, isolated from the endophytic fungus S20 of Cephalotaxus hainanensis, was elucidated as 1-(5-methyl-1H-pyrrol-2-yl)-2-((2S*,3R*)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone (1) on the basis of spectroscopic evidence, including 1D- and 2D-NMR (HMQC, 1H-1H COSY, HMBC and ROESY) and MS analysis. Compound 1 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology*
  • Cephalotaxus / microbiology*
  • Ethylene Oxide / analogs & derivatives*
  • Ethylene Oxide / chemistry
  • Ethylene Oxide / pharmacology
  • Fermentation
  • Fungi / chemistry*
  • Fungi / metabolism
  • Magnetic Resonance Spectroscopy
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Pyrroles / chemistry
  • Pyrroles / pharmacology*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • 1-(5-methyl-1H-pyrrol-2-yl)-2-((2S,3R)-3-((E)-prop-1-enyl)oxiran-2-yl)ethanone
  • Anti-Bacterial Agents
  • Pyrroles
  • Ethylene Oxide