Two novel neo-clerodane diterpenoids from Scutellaria barbata

Bioorg Med Chem Lett. 2010 Jan 1;20(1):288-90. doi: 10.1016/j.bmcl.2009.10.116. Epub 2009 Nov 17.

Abstract

Two novel neo-clerodane diterpenoids, barbatellarines A (1) and B (2), were isolated from the whole plants of Scutellaria barbata, along with the known compound scutebarbatine F (3). The chemical structures and relative stereochemistry of the isolated compounds were established by NMR (1D and 2D) and mass spectroscopic analyses. Compounds 2 and 3 were evaluated for in vitro cytotoxic activity against the HL-60 (human leukemia), MCF7 (human breast cancer), and LLC (Lewis lung carcinoma) cancer cell lines. Compound 2 exhibited weak cytotoxic activity against HL-60 cells, with an IC(50) value of 41.4microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity
  • Cell Line, Tumor
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / toxicity
  • Diterpenes, Clerodane / chemistry*
  • Diterpenes, Clerodane / isolation & purification
  • Diterpenes, Clerodane / toxicity
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Scutellaria / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes
  • Diterpenes, Clerodane
  • barbatellarine A
  • barbatellarine B