Long-term observation of subunit vaccine F1-rV270 against Yersinia pestis in mice

Zuyun Wang; Lei Zhou; Zhizhen Qi; Qingwen Zhang; Ruixia Dai; Yonghai Yang; Baizhong Cui; Hu Wang; Ruifu Yang; Xiaoyi Wang

doi:10.1128/CVI.00305-09

Long-term observation of subunit vaccine F1-rV270 against Yersinia pestis in mice

Clin Vaccine Immunol. 2010 Jan;17(1):199-201. doi: 10.1128/CVI.00305-09. Epub 2009 Nov 25.

Authors

Zuyun Wang¹, Lei Zhou, Zhizhen Qi, Qingwen Zhang, Ruixia Dai, Yonghai Yang, Baizhong Cui, Hu Wang, Ruifu Yang, Xiaoyi Wang

Affiliation

¹ Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.

Abstract

Long-term protection and antibody response for the subunit vaccine F1-rV270 were determined by using the mouse model. Antibodies to F1 and rV270 were still detectable over a period of 518 days. The complete protection against lethal challenge of Yersinia pestis could be achieved up to day 518 after primary immunization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Bacterial / blood
Antigens, Bacterial / genetics
Antigens, Bacterial / immunology*
Bacterial Proteins / genetics
Bacterial Proteins / immunology*
Female
Mice
Mice, Inbred BALB C
Plague / prevention & control*
Plague Vaccine / immunology*
Pore Forming Cytotoxic Proteins / genetics
Pore Forming Cytotoxic Proteins / immunology*
Survival Analysis
Vaccines, Subunit / immunology

Substances

Antibodies, Bacterial
Antigens, Bacterial
Bacterial Proteins
LcrV protein, Yersinia
Plague Vaccine
Pore Forming Cytotoxic Proteins
Vaccines, Subunit
caf1 protein, Yersinia pestis