Experimental and computational determination of tRNA dynamics

FEBS Lett. 2010 Jan 21;584(2):376-86. doi: 10.1016/j.febslet.2009.11.061.

Abstract

As the molecular representation of the genetic code, tRNA plays a central role in the translational machinery where it interacts with several proteins and other RNAs during the course of protein synthesis. These interactions exploit the dynamic flexibility of tRNA. In this minireview, we discuss the effects of modified bases, ions, and proteins on tRNA structure and dynamics and the challenges of observing its motions over the cycle of translation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Base Sequence
  • Conserved Sequence
  • Genetic Code*
  • Molecular Dynamics Simulation*
  • Nucleic Acid Conformation
  • Protein Conformation
  • Proteins / chemistry
  • Proteins / metabolism
  • RNA, Transfer / chemistry*
  • RNA, Transfer / genetics
  • RNA, Transfer / metabolism*

Substances

  • Proteins
  • RNA, Transfer