Rhodium-catalyzed enantioselective cyclopropanation of olefins with N-sulfonyl 1,2,3-triazoles

J Am Chem Soc. 2009 Dec 23;131(50):18034-5. doi: 10.1021/ja908075u.

Abstract

N-Sulfonyl 1,2,3-triazoles readily form rhodium(II) azavinyl carbenes, which react with olefins to produce cyclopropanes with excellent diastereo- and enantioselectivity and in high yield.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Aza Compounds / chemistry
  • Catalysis
  • Cyclization
  • Cyclopropanes / chemical synthesis*
  • Cyclopropanes / chemistry
  • Molecular Structure
  • Rhodium / chemistry*
  • Stereoisomerism
  • Sulfones / chemistry
  • Triazoles / chemistry*

Substances

  • Alkenes
  • Aza Compounds
  • Cyclopropanes
  • Sulfones
  • Triazoles
  • Rhodium