p53 and Metabolism: The GAMT Connection

Mol Cell. 2009 Nov 13;36(3):351-2. doi: 10.1016/j.molcel.2009.10.026.

Abstract

In this issue of Molecular Cell, Ide et al. (2009) have identified the enzyme guanidinoacetate methyltransferase (GAMT) that regulates creatine metabolism as a p53 target involved in apoptosis, reactive oxygen species (ROS), and fatty acid metabolism.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Creatine / biosynthesis
  • DNA Damage
  • Energy Metabolism*
  • Fatty Acids / metabolism
  • Glucose / pharmacology
  • Guanidinoacetate N-Methyltransferase / genetics
  • Guanidinoacetate N-Methyltransferase / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Biological
  • Oxidation-Reduction
  • Oxidative Stress
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Fatty Acids
  • Tumor Suppressor Protein p53
  • Gamt protein, mouse
  • Guanidinoacetate N-Methyltransferase
  • Glucose
  • Creatine