Characterization of a novel TPMT mutation associated with azathioprine-induced myelosuppression

Br J Clin Pharmacol. 2009 Nov;68(5):770-2. doi: 10.1111/j.1365-2125.2009.03439.x.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antimetabolites / therapeutic use*
  • Azathioprine / therapeutic use*
  • Child
  • Female
  • Humans
  • Inflammatory Bowel Diseases / drug therapy*
  • Inflammatory Bowel Diseases / genetics
  • Inflammatory Bowel Diseases / metabolism
  • Methyltransferases / drug effects*
  • Methyltransferases / genetics
  • Mutation
  • Pedigree
  • Polymorphism, Genetic / genetics*
  • Treatment Outcome

Substances

  • Antimetabolites
  • Methyltransferases
  • thiopurine methyltransferase
  • Azathioprine