Biological background of dermal substitutes

Vincent C van der Veen; Martijn B A van der Wal; Michiel C E van Leeuwen; Magda M W Ulrich; Esther Middelkoop

doi:10.1016/j.burns.2009.07.012

Biological background of dermal substitutes

Burns. 2010 May;36(3):305-21. doi: 10.1016/j.burns.2009.07.012. Epub 2009 Nov 7.

Authors

Vincent C van der Veen¹, Martijn B A van der Wal, Michiel C E van Leeuwen, Magda M W Ulrich, Esther Middelkoop

Affiliation

¹ Association of Dutch Burn Centers, Beverwijk, The Netherlands.

PMID: 19897310
DOI: 10.1016/j.burns.2009.07.012

Abstract

Dermal substitutes are of major importance in treating full thickness skin defects, both in acute and chronic wounds. In this review we will outline specific requirements of three classes of dermal substitutes: Biological and clinical requirements will be translated to composition, physical structure, immunological properties and cell-matrix interactions of the various materials. Important properties like pore size, cell adhesion sites (e.g. RGD sequences), crosslinking, degradability and the presence of a basement membrane will be discussed for each of the different classes of materials.

Publication types

Review

MeSH terms

Animals
Burns / therapy*
Disease Models, Animal
Humans
Materials Testing / methods
Skin Transplantation / methods
Skin, Artificial*
Sus scrofa
Treatment Outcome
Wound Healing