Abstract
An amphiphilic porphyrin appended with a Ru(II)-polypyridyl complex (Ru-P) showing a moderate two-photon absorption cross-section (178.0+/-26.8GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru-P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru-P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism*
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Antineoplastic Agents / therapeutic use
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Cell Line, Tumor
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Humans
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Imaging, Three-Dimensional*
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Organometallic Compounds / chemistry
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Organometallic Compounds / metabolism*
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Organometallic Compounds / therapeutic use
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Photochemotherapy*
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Photons
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / metabolism*
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Photosensitizing Agents / therapeutic use
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Spectrometry, Fluorescence
Substances
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Antineoplastic Agents
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Organometallic Compounds
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Photosensitizing Agents
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bis(bipyridine)(((10',15',20'-triphenyl)porphyrin(5'-p-phenoxy-5-ethanamido))-1,10-phenanthroline)ruthenium(II)