Abstract
A study of an EtOH extract obtained from the roots of the Madagascan plant Terminalia tropophylla H. Perrier (Combretaceae) led to isolation of the oleanane-type triterpenoid saponin 1, the lignan derivative 2, and the two known saponins arjunglucoside I (3) and sericoside (4). The structures of compounds 1 (terminaliaside A) and 2 (4'-O-cinnamoyl cleomiscosin A) were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compound 1 showed antiproliferative activity against the A2780 human ovarian cancer cell line with an IC(50) value of 1.2 microM.
2009 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Line, Tumor
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Ecosystem
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Female
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Humans
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Inhibitory Concentration 50
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Lignans / chemistry
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Lignans / isolation & purification*
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Madagascar
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Molecular Structure
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Oleanolic Acid / analogs & derivatives*
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Oleanolic Acid / chemistry
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Oleanolic Acid / isolation & purification
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Oleanolic Acid / pharmacology
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Ovarian Neoplasms / drug therapy*
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Phytotherapy
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
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Plant Roots / chemistry
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Terminalia / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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4'-O-cinnamoyl cleomiscosin A
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Antineoplastic Agents, Phytogenic
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Lignans
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Plant Extracts
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Saponins
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Triterpenes
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oleanane
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terminaliaside A
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Oleanolic Acid