Asymmetric addition of alkenylstannanes to alkylidene Meldrum's acids

Org Lett. 2009 Nov 19;11(22):5346-9. doi: 10.1021/ol902216y.

Abstract

Herein, we describe enantioselective addition of alkenyltin reagents possessing a reactive and sensitive allylic functionality not readily available to other classes of alkenyl metals. This method is enabled by the use of highly electrophilic alkylidene Meldrum's acids as acceptors and a cationic Rh(I)-diene complex as catalyst.