A case of osteosarcoma of the talus is reported. Osteosarcoma of the talus is very rare. The patient is alive and she has been continuously disease free for five years after surgery. This is the first case of osteosarcoma of the talus with reconstruction using a frozen bone method, an autograft containing tumor treated with liquid nitrogen. This is a rare case report of osteosarcoma of the talus without extrainvasion of the talus.