Type I and type II pathways of Fas-mediated apoptosis are differentially controlled by XIAP

Zhenyue Hao; Tak W Mak

doi:10.1093/jmcb/mjp034

Type I and type II pathways of Fas-mediated apoptosis are differentially controlled by XIAP

J Mol Cell Biol. 2010 Apr;2(2):63-4. doi: 10.1093/jmcb/mjp034. Epub 2009 Oct 16.

Authors

Zhenyue Hao¹, Tak W Mak

Affiliation

¹ The Campbell Family Cancer Research Institute, University Health Network, Toronto, ON, Canada. yhao@uhnres.utoronto.ca

PMID: 19837685
DOI: 10.1093/jmcb/mjp034

Abstract

The mechanism by which Fas activates the apoptotic pathway differs in so-called type I and type II cells. X chromosome-linked inhibitor of apoptosis protein has now been revealed as an important molecule that is differentially regulated in type I vs. type II cells.

MeSH terms

Animals
Apoptosis*
Mice
Mice, Knockout
Signal Transduction*
X-Linked Inhibitor of Apoptosis Protein / metabolism*
fas Receptor / metabolism*

Substances

Fas protein, mouse
X-Linked Inhibitor of Apoptosis Protein
fas Receptor