Optical signal comparison of single fluorescent molecules and Raman active gold nanostars

Nano Lett. 2009 Nov;9(11):3816-9. doi: 10.1021/nl902008g.

Abstract

The relevant photophysical properties of single fluorescent molecules and single SERS active surface-coated gold nanostars tagged with the Raman reporter molecule 4-mercaptopyridine are compared for imaging purposes. Mean count rate distributions are built from the single molecule/single probe level. The individually observed variance and count rates of both systems are compared as well as the behavior over multiple image acquisitions.