Synthesis and pharmacological properties of nebivolol, a new antihypertensive compound

J Pharm Belg. 1990 Nov-Dec;45(6):355-60.

Abstract

The synthesis of alpha,alpha' (iminobis(methylene]-bis-(3,4-dihydro-2H-1benzopyran-2-metha nol) derivatives and the stereochemistry and pharmacological profile of this new class of antihypertensive compounds are described. Finally, the selection and pharmacological profile of the preferred compound of this series, nebivolol and its enantiomers, is discussed.

MeSH terms

  • Adrenergic beta-Antagonists / chemical synthesis*
  • Adrenergic beta-Antagonists / chemistry
  • Adrenergic beta-Antagonists / pharmacology
  • Animals
  • Benzopyrans / chemical synthesis*
  • Benzopyrans / chemistry
  • Benzopyrans / pharmacology
  • Ethanolamines / chemical synthesis*
  • Ethanolamines / chemistry
  • Ethanolamines / pharmacology
  • Guinea Pigs
  • In Vitro Techniques
  • Isomerism
  • Nebivolol
  • Rabbits
  • Rats

Substances

  • Adrenergic beta-Antagonists
  • Benzopyrans
  • Ethanolamines
  • Nebivolol