Abstract
Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism
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Animals
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Caspase 8 / metabolism
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Cell Death
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Cullin Proteins / metabolism
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Heat-Shock Proteins / metabolism
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Mice
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Sequestosome-1 Protein
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TNF-Related Apoptosis-Inducing Ligand / metabolism
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Ubiquitination*
Substances
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Adaptor Proteins, Signal Transducing
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Cullin Proteins
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Heat-Shock Proteins
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Sequestosome-1 Protein
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Sqstm1 protein, mouse
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TNF-Related Apoptosis-Inducing Ligand
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Caspase 8