Cross-coupling of alkenyl/aryl carboxylates with Grignard reagent via Fe-catalyzed C-O bond activation

Bi-Jie Li; Li Xu; Zhen-Hua Wu; Bing-Tao Guan; Chang-Liang Sun; Bi-Qin Wang; Zhang-Jie Shi

doi:10.1021/ja907281f

Cross-coupling of alkenyl/aryl carboxylates with Grignard reagent via Fe-catalyzed C-O bond activation

J Am Chem Soc. 2009 Oct 21;131(41):14656-7. doi: 10.1021/ja907281f.

Authors

Bi-Jie Li¹, Li Xu, Zhen-Hua Wu, Bing-Tao Guan, Chang-Liang Sun, Bi-Qin Wang, Zhang-Jie Shi

Affiliation

¹ Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China.

PMID: 19788187
DOI: 10.1021/ja907281f

Abstract

Iron-catalyzed cross-coupling of alkenyl/aryl carboxylates with primary alkyl Grignard reagent was described. This reaction brought a new family of electrophiles to iron catalysis. The combination of an inexpensive carboxylate electrophile and an iron catalyst would generate ample advantages.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemistry*
Carbon / chemistry*
Carboxylic Acids / chemistry*
Catalysis
Indicators and Reagents / chemistry
Iron / chemistry*
Oxygen / chemistry*

Substances

Alkenes
Carboxylic Acids
Indicators and Reagents
Carbon
Iron
Oxygen