Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase

Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Models, Molecular
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / enzymology*
  • Peptide Synthases / antagonists & inhibitors*
  • Peptide Synthases / chemistry
  • Peptide Synthases / metabolism
  • Protein Conformation
  • Stereoisomerism

Substances

  • Enzyme Inhibitors
  • Peptide Synthases
  • pantothenate synthetase