Manufacture of pharmaceutical co-crystals using twin screw extrusion: a solvent-less and scalable process

J Pharm Sci. 2010 Apr;99(4):1693-6. doi: 10.1002/jps.21942.
No abstract available

Publication types

  • Evaluation Study

MeSH terms

  • Benzothiazoles / chemistry
  • Caffeine / chemistry
  • Crystallization / methods*
  • Drug Compounding / methods*
  • Oxalic Acid / chemistry
  • Pyrimidines / chemistry
  • Solubility
  • Sorbic Acid / chemistry
  • X-Ray Diffraction

Substances

  • Benzothiazoles
  • N-(4-(6-(4-trifluoromethylphenyl)pyrimidin-4-yloxy)benzothiazol-2-yl)acetamide
  • Pyrimidines
  • Caffeine
  • Oxalic Acid
  • Sorbic Acid