Abstract
The furanoditerpenoids voucapane, voucapane-6alpha,7alpha-diol, voucapane-18,19-diol and 18-hydroxyvoucapan-19-al were isolated from the cytotoxic stem and root bark extracts of Stuhlmaniamoavi Verdc. (Ceasalpiniaceae) and their structures established based on analysis of spectroscopic data. The compounds exhibited anti-proliferative, cytotoxic, antibacterial and antifungal activities, 18-hydroxyvoucapan-19-al showing the highest anti-proliferative and cytotoxic properties. Voucapane-18,19-diol was only mildly active but the activity was enhanced for its 18,19-di-(4-methyl)-benzenesulphonate. Some of these results thus corroborate the traditional medicinal uses of the crude extracts for the treatment of skin infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Artemia
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes / therapeutic use*
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Humans
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Magnoliopsida / chemistry*
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Mice
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Neoplasms / drug therapy*
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Phytotherapy*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Plant Structures
Substances
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18-hydroxyvoucapan-19-al
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Anti-Bacterial Agents
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Antifungal Agents
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Plant Extracts