4-1BB as a therapeutic target for human disease

Seung-Woo Lee; Michael Croft

doi:10.1007/978-0-387-89520-8_8

4-1BB as a therapeutic target for human disease

Adv Exp Med Biol. 2009:647:120-9. doi: 10.1007/978-0-387-89520-8_8.

Authors

Seung-Woo Lee¹, Michael Croft

Affiliation

¹ Molecular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, California, 92037, USA.

PMID: 19760070
DOI: 10.1007/978-0-387-89520-8_8

Abstract

4-1BB (CD137) is being thought of as an attractive target for immunotherapy of many human immune diseases based on encouraging results with 4-1BB agonistic antibody treatment in mouse models of cancer, autoimmune disease, asthma and additionally as a means to improve vaccination. In this review, we will summarize the results of basic research on 4-1BB and 4-1BB immunotherapy of disease and provide some potential mechanistic insights into the many stimulatory and regulatory functions of 4-1BB.

Publication types

Review

MeSH terms

Animals
Autoimmune Diseases / therapy*
Humans
Mice
Neoplasms / therapy*
Tumor Necrosis Factor Receptor Superfamily, Member 9 / antagonists & inhibitors*
Tumor Necrosis Factor Receptor Superfamily, Member 9 / metabolism

Substances

Tumor Necrosis Factor Receptor Superfamily, Member 9