Abstract
Recombinant Sindbis viruses were engineered to express alternative forms of the protective antigen (PA) of Bacillus anthracis. The recombinant viruses induced PA-specific immunoglobulin G and neutralizing antibodies in Swiss Webster mice. Vaccination with the recombinant viruses induced immunity that offered some protection from a lethal Ames strain spore challenge and synergized the protective effects of ciprofloxacin.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Anthrax / prevention & control*
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Anthrax Vaccines / genetics
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Anthrax Vaccines / immunology*
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Anti-Bacterial Agents / therapeutic use*
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Antibodies, Bacterial / blood
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Antibodies, Neutralizing / blood
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology*
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Bacillus anthracis / genetics*
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Bacterial Toxins / genetics
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Bacterial Toxins / immunology*
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Ciprofloxacin / therapeutic use*
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Genetic Vectors*
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Humans
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Immunoglobulin G / blood
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Mice
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Sindbis Virus / genetics*
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Sindbis Virus / immunology
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Survival Analysis
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Vaccines, Synthetic / genetics
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Vaccines, Synthetic / immunology
Substances
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Anthrax Vaccines
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Anti-Bacterial Agents
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Antibodies, Bacterial
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Antibodies, Neutralizing
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Antigens, Bacterial
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Bacterial Toxins
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Immunoglobulin G
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Vaccines, Synthetic
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anthrax toxin
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Ciprofloxacin