Mobilization of the gentamicin resistance gene in Enterococcus faecalis

Antimicrob Agents Chemother. 1990 Jun;34(6):1278-80. doi: 10.1128/AAC.34.6.1278.

Abstract

Enterococcus faecalis plasmid pBEM10 (a conjugative plasmid encoding beta-lactamase production and gentamicin resistance [Gmr]) was made transfer deficient by using Tn917. Relocation of the Gmr determinant into two sites on pCF10 was observed. Restriction analysis revealed insertion of a common 2.5-kilobase-pair HindIII and a 3.9-kilobase-pair HaeIII fragment encoding Gmr, suggesting that this determinant resides on a transposon similar to Tn4001.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Probes
  • DNA Transposable Elements / physiology
  • Drug Resistance, Microbial / genetics
  • Enterococcus faecalis / genetics*
  • Genes, Bacterial / physiology*
  • Gentamicins / pharmacology*
  • Plasmids / genetics
  • Polymorphism, Restriction Fragment Length

Substances

  • DNA Probes
  • DNA Transposable Elements
  • Gentamicins