Abstract
Leptin is an adipokine that modulates multiple functions including energy homeostasis, thermoregulation, bone metabolism, endocrine and pro-inflammatory immune responses. Several studies have implicated leptin in the pathogenesis of chronic autoimmune inflammatory conditions such as autoimmune encephalomyelitis, intestinal bowel inflammation and type-1 diabetes. This review focuses on the role of leptin in non-autoimmune inflammatory diseases that include renal, liver and lung inflammation, atherosclerosis and metabolic syndrome, Behçet's disease and endometriosis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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Inflammation
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Leptin / genetics
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Leptin / immunology*
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Leptin / metabolism*
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Leptin / therapeutic use
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Lipid Metabolism
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Metabolic Diseases / drug therapy
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Metabolic Diseases / immunology*
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Metabolic Diseases / metabolism
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Metabolic Diseases / physiopathology
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Oxidative Stress
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology*
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Recombinant Proteins / metabolism*
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Recombinant Proteins / therapeutic use
Substances
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Leptin
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Recombinant Proteins