Abstract
In this work we report the characterization of plasmid pCTX-M360, isolated from a Klebsiella pneumoniae strain from China and encoding the CTX-M-3 extended-spectrum beta-lactamase. Sequence analysis of pCTX-M360 revealed extensive similarity with pEL60 and pCTX-M3, two other enterobacterial plasmids of the IncL/M incompatibility group. Compared to pEL60, pCTX-M360 contains several insertions but lacks most of a 27-kb insert found in pCTX-M3, suggesting that it could be an evolutionary intermediate between pEL60 and pCTX-M3.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics*
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Bacterial Proteins / physiology
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China
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DNA Transposable Elements / genetics
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Drug Resistance, Multiple, Bacterial / genetics
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Humans
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / enzymology*
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Klebsiella pneumoniae / genetics*
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Models, Genetic
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Molecular Sequence Data
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Plasmids / genetics*
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beta-Lactamases / genetics*
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beta-Lactamases / physiology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA Transposable Elements
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beta-Lactamases