Degradation of cytoplasmic substrates by FtsH, a membrane-anchored protease with many talents

Franz Narberhaus; Markus Obrist; Frank Führer; Sina Langklotz

doi:10.1016/j.resmic.2009.08.011

Degradation of cytoplasmic substrates by FtsH, a membrane-anchored protease with many talents

Res Microbiol. 2009 Nov;160(9):652-9. doi: 10.1016/j.resmic.2009.08.011. Epub 2009 Sep 8.

Authors

Franz Narberhaus¹, Markus Obrist, Frank Führer, Sina Langklotz

Affiliation

¹ Ruhr-Universität Bochum, Lehrstuhl für Biologie der Mikroorganismen, Bochum, Germany. franz.narberhaus@rub.de

PMID: 19744556
DOI: 10.1016/j.resmic.2009.08.011

Abstract

Control of cellular processes by regulated proteolysis is conserved among all organisms. FtsH, the only membrane-anchored AAA protease in bacteria, fulfills a variety of regulatory functions. This review focuses on soluble FtsH substrates in Escherichia coli and in other bacteria and outlines emerging substrate recognition principles.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP-Dependent Proteases / chemistry
ATP-Dependent Proteases / metabolism*
Amidohydrolases / metabolism
Biocatalysis
Cell Membrane / enzymology*
Cytoplasm / enzymology*
Escherichia coli Proteins / chemistry
Escherichia coli Proteins / metabolism*
Membrane Proteins / metabolism
Substrate Specificity

Substances

Escherichia coli Proteins
Membrane Proteins
ATP-Dependent Proteases
FtsH protein, E coli
Amidohydrolases
UDP-3-O-acyl-N-acetylglucosamine deacetylase