Abstract
Objective:
We investigated the change of antipsychotic treatment of elderly persons with dementia after several publications indicated an association between use of antipsychotics and cerebrovascular events in this population.
Methods:
Twice a year, the complete medication, age, diagnosis and gender of all inpatients in 30 German psychiatric sites is collected anonymously in a data base for statistical analysis.
Results:
The treatment changed for the benefit of Quetiapine and Haloperidol. The use of both Risperidone and Olanzapine decreased markedly.
Conclusion:
The antipsychotic treatment changed due to critical publication. But, the evidence for the risk profile is still a matter of debate.
MeSH terms
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Adverse Drug Reaction Reporting Systems / statistics & numerical data
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Aged
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Alzheimer Disease / drug therapy*
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Alzheimer Disease / epidemiology
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Antipsychotic Agents / adverse effects*
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Antipsychotic Agents / therapeutic use*
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Cerebral Infarction / chemically induced*
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Cerebral Infarction / epidemiology
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Dibenzothiazepines / adverse effects
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Dibenzothiazepines / therapeutic use
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Drug Therapy, Combination
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Drug Utilization / statistics & numerical data
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Drug-Related Side Effects and Adverse Reactions
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Evidence-Based Medicine / statistics & numerical data
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Female
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Germany
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Humans
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Male
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Practice Patterns, Physicians' / statistics & numerical data
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Publication Bias / statistics & numerical data*
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Quetiapine Fumarate
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Risk
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Risperidone / adverse effects
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Risperidone / therapeutic use
Substances
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Antipsychotic Agents
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Dibenzothiazepines
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Quetiapine Fumarate
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Risperidone