Getting a "Hold" on NPC2

Cell Metab. 2009 Sep;10(3):161-2. doi: 10.1016/j.cmet.2009.08.006.

Abstract

Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

Publication types

  • Comment

MeSH terms

  • Carrier Proteins / metabolism*
  • Cholesterol / metabolism
  • Glycoproteins / metabolism*
  • Humans
  • RNA, Small Interfering / metabolism
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Vesicular Transport Proteins

Substances

  • Carrier Proteins
  • Glycoproteins
  • NPC2 protein, human
  • NUS1 protein, human
  • RNA, Small Interfering
  • Receptors, Cell Surface
  • Vesicular Transport Proteins
  • Cholesterol