Nucleic acid-induced aggregation and pyrene excimer formation

Ruixing Zhang; Dan Tang; Ping Lu; Xiangyu Yang; Dongli Liao; Yujing Zhang; Mingjun Zhang; Cong Yu; Vivian W W Yam

doi:10.1021/ol901607g

Nucleic acid-induced aggregation and pyrene excimer formation

Org Lett. 2009 Oct 1;11(19):4302-5. doi: 10.1021/ol901607g.

Authors

Ruixing Zhang¹, Dan Tang, Ping Lu, Xiangyu Yang, Dongli Liao, Yujing Zhang, Mingjun Zhang, Cong Yu, Vivian W W Yam

Affiliation

¹ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.

PMID: 19722507
DOI: 10.1021/ol901607g

Abstract

Nucleic acid was found to induce the aggregation of the positively charged pyrene probe (compound 1); as a result, strong pyrene excimer emission was observed. The intensity of the excimer emission was dependent on the concentration of the pyrene probe and the oligonucleotide length, sequence, and concentration. These results suggest a new strategy for label-free nucleic acid-based biosensing applications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
Molecular Structure
Nucleic Acids / chemistry*
Pyrenes / chemical synthesis
Pyrenes / chemistry*

Substances

Fluorescent Dyes
Nucleic Acids
Pyrenes
pyrene