Abstract
The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Amides / toxicity
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Animals
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology
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Biofilms / drug effects*
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Caenorhabditis elegans / drug effects*
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / physiology
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Pyrroles / chemical synthesis*
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Pyrroles / pharmacology
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Pyrroles / toxicity
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis
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Sulfonamides / pharmacology
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Thiourea / chemical synthesis
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Thiourea / pharmacology
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Urea / chemical synthesis
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Urea / pharmacology
Substances
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Amides
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Anti-Bacterial Agents
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Pyrroles
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Sulfonamides
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Urea
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Thiourea
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oroidin