Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata

Jian-rong Dai; Gerald C Coles; Wei Wang; You-sheng Liang

doi:10.1016/j.trstmh.2009.07.015

Toxicity of a novel suspension concentrate of niclosamide against Biomphalaria glabrata

Trans R Soc Trop Med Hyg. 2010 Apr;104(4):304-6. doi: 10.1016/j.trstmh.2009.07.015. Epub 2009 Aug 28.

Authors

Jian-rong Dai¹, Gerald C Coles, Wei Wang, You-sheng Liang

Affiliation

¹ Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory on Molecular Biology of Parasites, Jiangsu Provincial Key Subject on Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China.

PMID: 19716575
DOI: 10.1016/j.trstmh.2009.07.015

Abstract

As a new suspension concentrate of niclosamide (SCN) was more effective in controlling Oncomelania snails than a wettable powder of the same drug, it was tested against Biomphalaria glabrata. There were no differences in the effect of the suspension concentrate, the wettable powder of niclosamide and ball-milled pure niclosamide against the adult snails, but at after 48h 0.125mg/l SCN killed 100% of eggs compared with 84.3% for WPN and 17.7% for pure niclosamide. Because of the improved handling characteristics of SCN over the other formulations, further field tests on Biompharia and Bulinus species are warranted.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticestodal Agents / toxicity*
Biomphalaria / drug effects*
Niclosamide / toxicity*
Schistosomiasis / prevention & control
Toxicity Tests

Substances

Anticestodal Agents
Niclosamide