Free transport of water and CO2 in nonporous hydrophobic clarithromycin form II crystals

J Am Chem Soc. 2009 Sep 23;131(37):13216-7. doi: 10.1021/ja904658p.

Abstract

Clarithromycin is a well-known antibiotic that exists in various polymorphic forms. This molecule can be sublimed to afford a guest-free form that displays the unexpected transport of molecules of water or carbon dioxide to voids within the channel-free crystal lattice.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Carbon Dioxide / chemistry*
  • Clarithromycin / chemistry*
  • Crystallography, X-Ray
  • Hydrophobic and Hydrophilic Interactions*
  • Models, Molecular
  • Molecular Conformation
  • Porosity
  • Temperature
  • Water / chemistry*

Substances

  • Anti-Bacterial Agents
  • Water
  • Carbon Dioxide
  • Clarithromycin