Trial of fluoxetine added to neuroleptics for treatment-resistant schizophrenic patients

Am J Psychiatry. 1990 Apr;147(4):492-4. doi: 10.1176/ajp.147.4.492.

Abstract

Mean ratings of positive and negative symptoms and depression significantly improved in nine treatment-resistant schizophrenic patients who completed a 6-week open trial of fluoxetine added to their neuroleptics. The authors identify differences between responders and nonresponders and recommend controlled trials.

Publication types

  • Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use*
  • Clinical Trials as Topic
  • Depression / drug therapy
  • Drug Therapy, Combination
  • Female
  • Fluoxetine / therapeutic use*
  • Humans
  • Male
  • Pilot Projects
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology

Substances

  • Antipsychotic Agents
  • Fluoxetine