Does perioperative glucocorticosteroid treatment correlate with disturbance in surgical wound healing after treatment of facial fractures? A retrospective study

J Oral Maxillofac Surg. 2009 Sep;67(9):1884-8. doi: 10.1016/j.joms.2009.04.089.

Abstract

Purpose: To clarify whether perioperative glucocorticosteroid treatment used in association with repair of facial fractures predisposes to disturbance in surgical wound healing (DSWH).

Patients and methods: Retrospective review of records of patients who had undergone open reduction, with or without ostheosynthesis, or had received reconstruction of orbital wall fractures during the 2-year period from 2003 to 2004.

Results: Steroids were administered to 100 patients (35.7%) out of a total of 280. Dexamethasone was most often used, with the most common regimen being dexamethasone 10 mg every 8 hours over 16 hours, with a total dose of 30 mg. The overall DSWH rate was 3.9%. The DSWH rate for patients who had received perioperative steroids was 6.0%, and the corresponding rate for patients who did not receive steroids was 2.8%. The difference was not statistically significant. An intraoral surgical approach remained the only significant predictor to DSWH.

Conclusions: With regard to DSWH, patients undergoing operative treatment of facial fractures can safely be administered doses of 30 mg or less of perioperative glucocorticosteroids equivalent to dexamethasone.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Female
  • Fracture Fixation, Internal
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / adverse effects*
  • Humans
  • Male
  • Mandibular Fractures / surgery
  • Middle Aged
  • Oral Surgical Procedures / adverse effects*
  • Orbital Fractures / surgery
  • Perioperative Care / adverse effects
  • Retrospective Studies
  • Skull Fractures / surgery*
  • Wound Healing / drug effects*
  • Young Adult
  • Zygomatic Fractures / surgery

Substances

  • Glucocorticoids