Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system

XiaWei Wei; ChangYang Gong; MaLing Gou; ShaoZhi Fu; QingFa Guo; Shuai Shi; Feng Luo; Gang Guo; LiYan Qiu; ZhiYong Qian

doi:10.1016/j.ijpharm.2009.07.033

Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) copolymers as drug delivery system

Int J Pharm. 2009 Oct 20;381(1):1-18. doi: 10.1016/j.ijpharm.2009.07.033. Epub 2009 Aug 5.

Authors

XiaWei Wei¹, ChangYang Gong, MaLing Gou, ShaoZhi Fu, QingFa Guo, Shuai Shi, Feng Luo, Gang Guo, LiYan Qiu, ZhiYong Qian

Affiliation

¹ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

PMID: 19664700
DOI: 10.1016/j.ijpharm.2009.07.033

Abstract

Poly(epsilon-caprolactone)-poly(ethylene glycol) (PCL-PEG) copolymers are important synthetic biomedical materials with amphiphilicity, controlled biodegradability, and great biocompatibility. They have great potential application in the fields of nanotechnology, tissue engineering, pharmaceutics, and medicinal chemistry. This review introduced several aspects of PCL-PEG copolymers, including synthetic chemistry, PCL-PEG micro/nanoparticles, PCL-PEG hydrogels, and physicochemical and toxicological properties.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials / chemistry
Biodegradation, Environmental
Drug Carriers*
Ethylene Glycols / chemical synthesis
Ethylene Glycols / chemistry*
Ethylene Glycols / toxicity
Humans
Hydrogels / chemistry
Nanoparticles / chemistry
Polyesters / chemical synthesis
Polyesters / chemistry*
Polyesters / toxicity

Substances

Biocompatible Materials
Drug Carriers
Ethylene Glycols
Hydrogels
Polyesters
poly(epsilon-caprolactone)-b-poly(ethylene glycol)