Visualization of phase retardation of deep posterior eye by polarization-sensitive swept-source optical coherence tomography with 1-microm probe

Opt Express. 2009 Jul 20;17(15):12385-96. doi: 10.1364/oe.17.012385.

Abstract

Polarization-sensitive optical coherence tomography (PS-OCT) can measure cross-sectional and volumetric images of birefringence in fibrous tissues that provides additional contrast to the intensity images. In this study, we develop polarization-sensitive swept-source OCT (PS-SS-OCT) at 1 microm for deep penetration of the sclera and lamina cribrosa in the posterior part of human eyes. A calibration method for polarization mode dispersion of a circulator, which is employed to conserve the optical power of the interferometer and achieve system sensitivity sufficient for retinal imaging is demonstrated. The A-scan rate, the axial resolution, and the sensitivity of the PS-SS-OCT are 28,000 Hz, 11.0 microm, 94.2 dB, respectively. The posterior part of the eyes of a healthy male subject are measured in vivo. Phase-retardation images show birefringence of deep sclera and lamina cribrosa and enhance the contrast which is not visible in the intensity images. In addition, unlike conventional OCT, our PS-SS-OCT showed polarization-insensitive intensity images, in which an artifact created by the birefringence of sclera has been successfully eliminated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calibration
  • Choroid / pathology
  • Equipment Design
  • Humans
  • Interferometry / methods*
  • Male
  • Models, Statistical
  • Optics and Photonics
  • Retina / pathology*
  • Sclera / pathology
  • Sensitivity and Specificity
  • Tomography, Optical Coherence / instrumentation*
  • Tomography, Optical Coherence / methods*