[Biphenotypic acute leukaemia with Burkitt-like cytology]

Ann Biol Clin (Paris). 2009 Jul-Aug;67(4):437-40. doi: 10.1684/abc.2009.0337.
[Article in French]

Abstract

Biphenotypic acute leukaemia (BAL) represents about 5% of adult acute leukaemia. Based on a previously described scoring system, the European Group for Immunologic Classification of Leukaemia (EGIL) proposed a set of diagnostic criteria for BAL. This scoring system is based on the number and degree of the specificity of several markers for myeloid or T/B lymphoid blasts. Here, we report the case of a BAL with Burkitt-like cytology, corresponding to "the acute lymphoblastic leukaemia, Burkitt type" L3 for the FAB classification. By flow cytometry, the blasts showed a positivity for B lymphoid cytoplasmic (CD79a and mu) and membrane (CD19, CD22, CD24, IgM) markers AND a positivity for the myeloid (CD13, CD33, CD65, CD15) markers.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Blast Crisis / pathology
  • Burkitt Lymphoma / pathology
  • Flow Cytometry / methods
  • Humans
  • Leukemia, Biphenotypic, Acute / classification
  • Leukemia, Biphenotypic, Acute / epidemiology
  • Leukemia, Biphenotypic, Acute / genetics*
  • Leukemia, Biphenotypic, Acute / pathology