Abstract
A 56-year-old man was admitted to our hospital for the surgical removal of renal cell carcinoma (RCC). He was diagnosed with acromegaly due to his characteristic clinical features, endocrine data, and the presence of pituitary tumor. He was found to have colon cancer and follicular thyroid tumor. Pathological examination of the pituitary tumor after transsphenoidal surgery was compatible with growth hormone (GH)-secreting pituitary adenoma. We also detected the transcripts and/or immunoreactivity of GH/insulin-like growth factor I components in the tumor specimen. This is a rare case of acromegaly associated with multiple tumors, including RCC, colon cancer and thyroid tumor.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Acromegaly / etiology*
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Base Sequence
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Carcinoma, Renal Cell / complications
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Carcinoma, Renal Cell / genetics
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Carcinoma, Renal Cell / metabolism
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Colonic Neoplasms / complications
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Colonic Neoplasms / genetics
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Colonic Neoplasms / metabolism
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DNA Primers / genetics
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Gene Expression
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Humans
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Immunohistochemistry
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism
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Kidney Neoplasms / complications
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Kidney Neoplasms / genetics
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Kidney Neoplasms / metabolism
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Male
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Middle Aged
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Neoplasms, Multiple Primary / complications*
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Neoplasms, Multiple Primary / diagnosis
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / metabolism
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Pituitary Neoplasms / complications
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Pituitary Neoplasms / genetics
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Pituitary Neoplasms / metabolism
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Receptor, IGF Type 1 / genetics
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Receptor, IGF Type 1 / metabolism
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Receptors, Somatotropin / genetics
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Receptors, Somatotropin / metabolism
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Thyroid Neoplasms / complications
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Thyroid Neoplasms / genetics
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Thyroid Neoplasms / metabolism
Substances
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DNA Primers
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Receptors, Somatotropin
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Insulin-Like Growth Factor I
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Receptor, IGF Type 1