IL-33 raises alarm

Immunity. 2009 Jul 17;31(1):5-7. doi: 10.1016/j.immuni.2009.06.011.

Abstract

The interleukin-1 (IL-1)-like cytokine IL-33 is widely assumed to undergo proteolytic maturation by caspase-1. In this issue of Immunity, Lüthi et al. (2009) show that IL-33 is not a caspase-1 substrate. IL-33 is inactivated by caspase-3 and -7 to prevent an inappropriate immune response during apoptosis, but not in necrosis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Caspase 1 / immunology
  • Caspase 1 / metabolism
  • Caspase 3 / immunology
  • Caspase 3 / metabolism
  • Caspase 7 / immunology
  • Caspase 7 / metabolism
  • Cell Death / immunology*
  • Cytokines / immunology
  • Cytokines / metabolism
  • Endothelial Cells / immunology*
  • Endothelial Cells / metabolism
  • Humans
  • Interleukin-33
  • Interleukins / immunology*
  • Interleukins / metabolism

Substances

  • Cytokines
  • IL33 protein, human
  • Il33 protein, mouse
  • Interleukin-33
  • Interleukins
  • Caspase 3
  • Caspase 7
  • Caspase 1