Pancreas allograft thrombosis following intravenous immunoglobulin administration to treat parvovirus B19 infection

A S R Muthusamy; A C Vaidya; S Sinha; S F Atabani; T Haque; G Jones; J Cunningham; P J Friend

doi:10.1111/j.1399-3062.2009.00419.x

Pancreas allograft thrombosis following intravenous immunoglobulin administration to treat parvovirus B19 infection

Transpl Infect Dis. 2009 Oct;11(5):463-6. doi: 10.1111/j.1399-3062.2009.00419.x. Epub 2009 Jul 5.

Authors

A S R Muthusamy¹, A C Vaidya, S Sinha, S F Atabani, T Haque, G Jones, J Cunningham, P J Friend

Affiliation

¹ Oxford Transplant Centre, Churchill Hospital, Oxford, UK.

PMID: 19594866
DOI: 10.1111/j.1399-3062.2009.00419.x

Abstract

Pancreas graft thrombosis is one of the commonest non-immunological causes for early graft loss after transplantation. This case report describes a patient who developed graft thrombosis after intravenous immunoglobulin administration to treat acute parvovirus B19 infection. The potential role of hypercoagulability in graft thrombosis and the implications for immunoglobulin therapy in transplant patients with hypercoagulable states is discussed.

Publication types

Case Reports

MeSH terms

Adult
Blood Coagulation / physiology
Female
Humans
Immunoglobulins, Intravenous* / adverse effects
Immunoglobulins, Intravenous* / therapeutic use
Immunologic Factors* / adverse effects
Immunologic Factors* / therapeutic use
Pancreas Transplantation / adverse effects*
Parvoviridae Infections / immunology
Parvoviridae Infections / therapy*
Parvovirus B19, Human / immunology*
Thrombosis / etiology*
Transplantation, Homologous / adverse effects*

Substances

Immunoglobulins, Intravenous
Immunologic Factors