Palladium(II)-catalyzed ortho alkylation of benzoic acids with alkyl halides

Angew Chem Int Ed Engl. 2009;48(33):6097-100. doi: 10.1002/anie.200902262.

Abstract

The first Pd(II)-catalyzed alkylation of aryl C–H bonds is achieved without using a co-oxidant. The alkylation reaction was followed thereafter by an intramolecular lactonization to give broadly useful γ– and ™– benzolactones.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkylation
  • Benzoates / chemistry*
  • Catalysis
  • Halogens / chemistry*
  • Lactones / chemistry
  • Palladium / chemistry*

Substances

  • Benzoates
  • Halogens
  • Lactones
  • Palladium