Successful pregnancy following allogeneic bone marrow transplantation after conditioning by thoraco-abdominal irradiation

Bone Marrow Transplant. 1991 Sep;8(3):229-30.

Abstract

A 26-year-old woman delivered a normal child 5 years after bone marrow transplantation for severe aplastic anemia. The conditioning regimen comprised high dose cyclophosphamide and thoraco-abdominal irradiation (6 Gy). This and two previous cases demonstrate that normal pregnancy can follow total body or thoracoabdominal irradiation.

Publication types

  • Case Reports

MeSH terms

  • Abdomen / radiation effects*
  • Adult
  • Anemia, Aplastic / drug therapy
  • Anemia, Aplastic / radiotherapy
  • Anemia, Aplastic / surgery
  • Bone Marrow Transplantation*
  • Combined Modality Therapy
  • Cyclophosphamide / therapeutic use
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Pregnancy / drug effects
  • Pregnancy / radiation effects*
  • Pregnancy Outcome
  • Thorax / radiation effects*
  • Transplantation, Homologous
  • Whole-Body Irradiation

Substances

  • Cyclophosphamide