Ruthenium-catalyzed [2 + 2] cycloadditions of bicyclic alkenes with alkynyl phosphonates

J Org Chem. 2009 Aug 7;74(15):5762-5. doi: 10.1021/jo9010206.

Abstract

Ruthenium-catalyzed [2 + 2] cycloadditions of bicyclic alkenes with alkynyl phosphonates were investigated. The phosphonate moieties were found to be compatible with the Ru-catalyzed cycloadditions giving the corresponding cyclobutene cycloadducts in low to excellent yield (up to 96%). Alkynyl phosphonates showed lower reactivity than other heteroatom-substituted alkynes such as alkynyl halides, ynamides, alkynyl sulfides, and alkynyl sulfones and required a higher reaction temperature and much longer reaction time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Alkynes / chemistry*
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organophosphonates / chemistry*
  • Ruthenium / chemistry*
  • Stereoisomerism

Substances

  • Alkenes
  • Alkynes
  • Organometallic Compounds
  • Organophosphonates
  • Ruthenium