Abstract
We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.
MeSH terms
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology*
-
Cell Line, Tumor
-
Cell Proliferation / drug effects
-
Circular Dichroism
-
Fibroblasts / drug effects
-
Fibroblasts / metabolism
-
G-Quadruplexes / drug effects*
-
Humans
-
Inhibitory Concentration 50
-
Ligands
-
Nylons / chemical synthesis
-
Nylons / chemistry
-
Nylons / pharmacology*
Substances
-
Antineoplastic Agents
-
Ligands
-
Nylons