Different thermal energy requirement for open complex formation by Escherichia coli RNA polymerase at two related promoters

Nucleic Acids Res. 1991 Nov 25;19(22):6113-8. doi: 10.1093/nar/19.22.6113.

Abstract

We have studied the effect of temperature on transcription initiation in vitro at two related promoters ga/Pcon and ga/P1, which have the same nucleotide sequence around the -10 region and transcription start site, but differ in upstream sequences. One of the promoters, ga/Pcon, carries the consensus -35 hexamer, 5'TTGACA 3', whilst ga/P1 contains a block of 'distortable' upstream sequences that allow promoter function in the absence of a -35 region consensus sequence. RNA polymerase can form complexes with both promoters at a range of temperatures. However, the thermal energy requirement for open complex formation differs: open complexes can form at ga/P1 at low temperatures, whereas ga/Pcon requires higher temperatures. The thermal energy requirement for transcription from preformed open complexes is the same for both promoters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Fingerprinting
  • DNA-Directed RNA Polymerases / genetics
  • DNA-Directed RNA Polymerases / metabolism*
  • Escherichia coli / enzymology*
  • Galactose / genetics
  • Molecular Sequence Data
  • Promoter Regions, Genetic*
  • Thermodynamics*
  • Transcription, Genetic*

Substances

  • DNA-Directed RNA Polymerases
  • Galactose