Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4799-801. doi: 10.1016/j.bmcl.2009.06.043. Epub 2009 Jun 14.

Abstract

The synthesis and SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported.

MeSH terms

  • Animals
  • Cats
  • Ether-A-Go-Go Potassium Channels / metabolism
  • Humans
  • Imidazolidines / chemical synthesis
  • Imidazolidines / chemistry*
  • Imidazolidines / pharmacology
  • Ligands
  • Positron-Emission Tomography*
  • Receptors, Dopamine D3 / antagonists & inhibitors*
  • Receptors, Dopamine D3 / metabolism
  • Structure-Activity Relationship

Substances

  • Ether-A-Go-Go Potassium Channels
  • Imidazolidines
  • KCNH1 protein, human
  • Ligands
  • Receptors, Dopamine D3