The molecular dating game: an antibody heavy chain hangs loose with a chaperone while waiting for its life partner

Mol Cell. 2009 Jun 26;34(6):635-6. doi: 10.1016/j.molcel.2009.06.006.

Abstract

In a recent issue of Molecular Cell, Feige et al. (2009) utilize the murine immunoglobulin system to shed light on a long-standing puzzle: how do cells coordinate folding of different polypeptides that ultimately form a complex?

Publication types

  • Comment

MeSH terms

  • Animals
  • Endoplasmic Reticulum Chaperone BiP
  • Heat-Shock Proteins / metabolism
  • Heat-Shock Proteins / physiology*
  • Immunoglobulin Light Chains / chemistry
  • Immunoglobulin Light Chains / metabolism*
  • Immunoglobulin gamma-Chains / chemistry
  • Immunoglobulin gamma-Chains / metabolism*
  • Mice
  • Models, Molecular
  • Protein Folding
  • Protein Structure, Quaternary

Substances

  • Endoplasmic Reticulum Chaperone BiP
  • Heat-Shock Proteins
  • Immunoglobulin Light Chains
  • Immunoglobulin gamma-Chains