Two new unprecedented acetonyl-bearing sesquiterpenes from the hainan sponge Dysidea fragilis

Chem Biodivers. 2009 Jun;6(6):858-63. doi: 10.1002/cbdv.200800108.

Abstract

Two new acetonyl-bearing sesquiterpenes, dysifragilisins A and B (1 and 2, resp.), have been isolated from the Hainan marine sponge Dysidea fragilis. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analyses and by comparison of their NMR data with those of structurally related compounds. A plausible biogenetic pathway is proposed for the origin of compounds 1 and 2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dysidea / chemistry*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Sesquiterpenes
  • dysifragilisin A
  • dysifragilisin B
  • PTPN1 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1